Please use this identifier to cite or link to this item: http://umt-ir.umt.edu.my:8080/handle/123456789/5878
Title: Morphological analysis on the toxic effect of manganese on Acanthamoeba sp. isolated from Setiu Wetland, Terengganu
Other Titles: An in vitro study
Authors: Fatimah Hashim
Nur Athirah Abdul Rahman
Nakisah Mat Amin
Keywords: Cytotoxicity
genotoxicity
alkaline comet assay
heavy metal
Issue Date: 2015
Publisher: Procedia Environmental Science
Abstract: Manganese (Mn) is one of the common pollutants found in aquatic environment that are difficult to destroy and very persistent in the water body. Excessive levels of Mn in the aquatic environment have threatened some of the aquatic organisms including free-living Acanthamoeba sp. In this study, Mn was assessed for its cytotoxicity and genotoxicity on Acanthamoeba sp. isolated from Setiu Wetland, Terengganu. IC50 value of Mn obtained was 24 ppm while morphological observation indicates that Acanthamoeba sp. underwent apoptotic and necrotic mode of cell death after exposure to Mn for 24 hours at 30°C. This metal is also able to induce mild genotoxicity towards the DNA of Acanthamoeba sp.
URI: http://hdl.handle.net/123456789/5878
Appears in Collections:Journal Articles



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