Please use this identifier to cite or link to this item: http://umt-ir.umt.edu.my:8080/handle/123456789/7104
Title: NUMERICAL ANALYSIS OF MATHEMATICAL MODELLING OF TUMOUR GROWTH WITH IMMUNOTHERAPY, CHEMOTHERAPY AND IMMUNOTHERAPY-CHEMOTHERAPY
Authors: MUSTAFA MAMAT
EDWIN SETIAWAN NUGRAHA
AGUS KARTONO
Keywords: mathematical model
ordinary differential equation
tumour growth
immunotherapy
chemotherapy
Issue Date: 2010
Publisher: Journal of Sustainability Science and Management
Abstract: It is known that a beneficial tumour-treatment approach for a single patient often involves the administration of more than one type of therapy. The question of how best to combine multiple tumour therapies is still open. In this research, we investigate the theoretical interaction of three treatment types (two biological therapies and chemotherapy). We analyse a mathematical model, in the form of a system of ordinary differential equations (ODEs), governing tumour growth on a cell-population level with combination immunotherapy and chemotherapy. We present an ordinary differential equations model to look at overall cell populations. Numerical simulation immunesequence and human parameter are presented. We study and compare between result of numerical simulations immunotherapyalone, chemotherapy alone andimmunotherapy-chemotherapy sequence treatments. The success of every treatment depends on the initial of tumour cells population. With the same population oftumour cells, our study shows that immunotherapy-chemotherapy sequence is more effective than immunotherapy alone or chemotherapy alone.
URI: http://hdl.handle.net/123456789/7104
Appears in Collections:Journal Articles

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