Abstract:
Study of benzoylthiourea derivatives has received immense attentions from
researchers worldwide due to their versatility in many fields. Owing to the great
potentials they offered, therefore, this research project was carried out. In this study,
twenty substituted-benzoylthiourea amino acid have been successfully synthesized
and characterized using FT-IR spectroscopy, UV-Vis spectrophotometer, NMR
spectroscopy and Mass Spectrometry. To be specific, sixteen new compounds have
been obtained, while four compounds have been previously reported. Compound 4-
MeOBTT was obtained as single crystal and it has been further characterized by
Single Crystal X-Ray Crystallography. The FT-IR spectra demonstrated the presence
of six important absorption bands of v(N-H), v(O-H), v(C=O-OH), v(C=O-NH),
v(C=C) and v(C=S) observed within range of 3171-3486 cm
-1
-1
, 2962-3302 cm
,
-1
1703-1768 cm
-1
, 1655-1703 cm
-1
, 1499-1560 cm
-1
and 703-795 cm
, respectively.
Meanwhile, UV-Vis spectra exhibited the presence of two chromophores
corresponded to the n-* and -* transitions. Proton NMR spectra displayed all of
the expected resonances of (-C=O-NH) and (-C=S-NH) appeared in the range of δH
9-12 ppm and 10-11 ppm. Whereas, the
13
C NMR spectra showed the existence of
three main resonances of C=S, C=O-OH and C=O-NH appeared downfield at
