Synthesis And Characterization Of Substituted-Benzoylthiourea Valine And Threonine Derivatives

Abstract

Study of benzoylthiourea derivatives has received immense attentions from researchers worldwide due to their versatility in many fields. Owing to the great potentials they offered, therefore, this research project was carried out. In this study, twenty substituted-benzoylthiourea amino acid have been successfully synthesized and characterized using FT-IR spectroscopy, UV-Vis spectrophotometer, NMR spectroscopy and Mass Spectrometry. To be specific, sixteen new compounds have been obtained, while four compounds have been previously reported. Compound 4- MeOBTT was obtained as single crystal and it has been further characterized by Single Crystal X-Ray Crystallography. The FT-IR spectra demonstrated the presence of six important absorption bands of v(N-H), v(O-H), v(C=O-OH), v(C=O-NH), v(C=C) and v(C=S) observed within range of 3171-3486 cm -1 -1 , 2962-3302 cm , -1 1703-1768 cm -1 , 1655-1703 cm -1 , 1499-1560 cm -1 and 703-795 cm , respectively. Meanwhile, UV-Vis spectra exhibited the presence of two chromophores corresponded to the n-* and -* transitions. Proton NMR spectra displayed all of the expected resonances of (-C=O-NH) and (-C=S-NH) appeared in the range of δH 9-12 ppm and 10-11 ppm. Whereas, the 13 C NMR spectra showed the existence of three main resonances of C=S, C=O-OH and C=O-NH appeared downfield at