Cytotoxicity, genotoxicity and quatitative structure-activity relationship (QSAR) studies of stnthesized carbonyl thiourea derivatives on acanthamoeba SPP. and human corneal epithelial cel

Abstract

Forty-four synthesized carbonyl thiourea derivatives were evaluated for their potential as anti-amoebic agent, aiming for a new discovery in Acanthamoeba keratitis treatment. The compounds were tested on four isolates of Acanthamoeba namely A. castellanii (CCAP 1501/2A), A. polyphaga (CCAP 1501/3A), Acanthamoeba sp. (Hospital Kuala Lumpur isolate) and Acanthamoeba sp. (Setiu Wetland isolate).