Abstract:
Sponge natural products research is guided by bioactivity test from crude extract.
Marine sponges especially from class Demospongiae are rich sources of bioactive
compounds. Toxicity effect of two crude extract from sponges, Aaptos sp. and Theonella
sp. collected from Perhentian Island has been studied using Aedes aegypti larvicidal
assay. Both sponges showed significance difference in variances (F-test, P < 0.05). The
toxicity against third instar Aedes aegypti larvae at 24-hour larvacidal activity was also
significantly different (Paired t-test, P < 0.05). Theonella sp. showed larvicidal activity
with LC00 at 0.0548 mg/ml while LC00 for Aaptos sp. was at 3.0827 mg/ml. The results
obtained from this study revealed that crude extract from Theonella sp. are promising as
larvicides against Aedes aegypti.
