Toxicity effect of crude extract from sponges (Theonella sp. and Aaptos sp.) on mosquito larvae aedes aegypti

Abstract

Sponge natural products research is guided by bioactivity test from crude extract. Marine sponges especially from class Demospongiae are rich sources of bioactive compounds. Toxicity effect of two crude extract from sponges, Aaptos sp. and Theonella sp. collected from Perhentian Island has been studied using Aedes aegypti larvicidal assay. Both sponges showed significance difference in variances (F-test, P < 0.05). The toxicity against third instar Aedes aegypti larvae at 24-hour larvacidal activity was also significantly different (Paired t-test, P < 0.05). Theonella sp. showed larvicidal activity with LC00 at 0.0548 mg/ml while LC00 for Aaptos sp. was at 3.0827 mg/ml. The results obtained from this study revealed that crude extract from Theonella sp. are promising as larvicides against Aedes aegypti.