Abstract:
The objectives of this research were to investigate the antifungal activities of two
extracts from free-living amoebae Acanthamoeba sp (AK and Pl) extracts on
Microsporum gypseum by looking at their minimum inhibition concentration (MIC)
values against the fungal species and identifying which amoeba extracts has the most
potential in antifungal activities. In this study, extracts of two free-living amoebae
obtained from Acanthamoeba sp (labelled as AK extract) and Acanthamoeba sp
(labelled as Pl extract) were tested on Microsporum gypseum. Mgypseum is one of
the pathogenic fungi that cause dermatophytosis, the infections of the skin, hair and
nails. The amoeba extracts AK and Pl with various concentrations (6, 3, and
l .5mg/ml) and (2, 1, and 0.5mg/ml) respectively were used, for the test on the fungus.
Results obtained from this study indicated that all the extracts used have no antifungal
activity against Mgypseum. There was no inhibition zone observed at all
concentration of the extracts used, indicating that both amoeba extracts have no
antifungal activities.
