Abstract:
Pasteurella multocida B:2 is a microorganism causing respiratory disease in
ruminant animals mainly cattle and water buffaloes. The hemorrhagic septicemia
disease causes high fatality rate towards many livestock in Asia. Oral vaccination is
a way to induce mucosa[ immunity in the host. The Gut-associated Lymphoid
Tissue (GALT) in the gastrointestinal tract plays an important role in activating and
inducing immune response towards the other mucosa[ site through oral vaccination.
Secretary lgA will be produced to prevent cellular attachment of the antigen on host
cell through activation of the immune response. The effectiveness of the oral
vaccination was proven having significant different of (p< 0.05) between the
control and the treatment group for the area of GALT and the number of
lymphocytes using ANOV A Two-Factor with Replication. However, there was no
significant different between the weeks (p>0.05) for both area of GALT and he
number of lymphocytes due to the fact that the Pasteurella multocida B:2 is a
microorganism which infect the lung. Migration of lymphocytes to the lung will
allow the mucosa[ site in the lung to increase the immunity towards Pasteurella
multocida B:2. Repeated doses of vaccine through oral administration are
suggested to enable the individual obtaining sufficient immunity.
