Cytotoxic effect of lysates of Acanthamoeba sp. and Acanthamoeba castellanii on MCF-7 cells line

Abstract

MCF-7 cells are human breast cancer cells, the second most common types of cancer that cause death among women. The significance of this study is to investigate the potential of extracts of amoebae as anti-cancer agent. Previous study conducted by Iliana (2005) showed that the number of CEM-SS cells was decreased after treated with Acanthamoeba lysates. In other study, Acanthamoeba was found to contain proteolytic enzymes which caused the degradation of extracellular components of corneal cells. In the present study, lysates of two Acanthamoeba species namely Acanthamoeba sp. (SW) and Acanthamoeba castellanii (IMR) were treated in vitro on MCF-7 cells line.